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Synthesis and Biologic Evaluation of a Radioiodinated Quinazolinone Derivative for Enzyme-Mediated Insolubilization Therapy

✍ Scribed by Ho, Nan-hui; Harapanhalli, Ravi S.; Dahman, Bassam A.; Chen, Kai; Wang, Ketai; Adelstein, S. James; Kassis, Amin I.

Book ID: 127390530
Publisher: American Chemical Society
Year: 2002
Tongue: English
Weight: 110 KB
Volume: 13
Category: Article
ISSN: 1043-1802
DOI: 10.1021/bc010093p

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## Abstract The expression of thymidine phosphorylase (TP) is strongly associated with angiogenesis in tumors and activation of antitumor agents. We designed a novel 5‐^125^I‐labeled 6‐(2‐iminoimidazolidinyl)methyluracil hydrochloride ([^125^I]5I6IMU‐HCl) to develop an effective radiotracer for __i