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Synthesis and bioevaluation of [18F]4-fluoro-m-hydroxyphenethylguanidine ([18F]4F-MHPG): A novel radiotracer for quantitative PET studies of cardiac sympathetic innervation

✍ Scribed by Jang, Keun Sam; Jung, Yong-Woon; Sherman, Phillip S.; Quesada, Carole A.; Gu, Guie; Raffel, David M.

Book ID
121270631
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
379 KB
Volume
23
Category
Article
ISSN
0960-894X

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✍ Reeti Katoch-Rouse; Andrew G. Horti πŸ“‚ Article πŸ“… 2003 πŸ› John Wiley and Sons 🌐 French βš– 91 KB

## Abstract The feasibility of nucleophilic displacement of bromide in the 4‐bromopyrazole ring with [^18^F]fluoride has been demonstrated by the synthesis of two radiolabeled compounds: __N__‐(piperidin‐1‐yl)‐5‐(4‐methoxyphenyl)‐1‐(2‐chlorophenyl)‐4‐[^18^F]fluoro‐1__H__‐pyrazole‐3‐carboxamide, ([^