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Synthesis and Preliminary Evaluation of 9-(4-[18F]-Fluoro-3-Hydroxymethylbutyl)Guanine ([18F]FHBG): A New Potential Imaging Agent for Viral Infection and Gene Therapy Using PET

โœ Scribed by Mian M Alauddin; Peter S Conti


Book ID
117688199
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
220 KB
Volume
25
Category
Article
ISSN
0969-8051

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The one step radiosynthesis of 2-amino-6-[ 18 F]fluoro-9-(4-hydroxy-3-hydroxymethylbutyl) purine (6-[ 18 F]fluoropenciclovir) 6 is reported. Radiolabeled product 6-[ 18 F]fluoropenciclovir 6 was prepared by radiofluorination of compound 4 with [ 18 F]KF and isolated by a silica Sep-Pak cartridge. Th