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Synthesis and biodistribution in mice of 99mTcN–DBODC–DMSEt

✍ Scribed by Shuye Yang; Xuebin Wang; Haixun Guo; Jian Liu; Fenglong Wang; Xianzhong Zhang

Publisher
John Wiley and Sons
Year
2009
Tongue
French
Weight
174 KB
Volume
52
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

Nitrido technetium(V)‐mixed ligand complex of ^99m^TcN–DBODC**–**DMSEt [DMSEt: Monoethyl ester of (meso) 2,3‐dimercaptosuccinic acid, DBODC: bis(2‐ethoxyethyl)carbamodithioate] has been prepared in a two‐step procedure by first reaction of ^99m^TcO with succinic dihydrazede in the presence of stannous chloride as a reducing agent and propylenediamine tetraacetic acid as a complexant, followed by the addition of DMSEt and DBODC. The complex was stable over 6 h at room temperature. The partition coefficient indicated that it was a hydrophilic complex. Biodistribution in mice demonstrated that the complex accumulated mainly in liver, lungs and kidneys. Copyright © 2009 John Wiley & Sons, Ltd.

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