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Synthesis and bioactivity of a fluorescence-labeled lipid A analogue

✍ Scribed by Masato Oikawa; Hiroki Furuta; Yasuo Suda; Shoichi Kusumoto

Publisher
Elsevier Science
Year
1999
Tongue
French
Weight
250 KB
Volume
40
Category
Article
ISSN
0040-4039

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✦ Synopsis

A fluorescence-labeled phosphonooxyethyi (PE) analogue of lipid A has been successfully synthesized in 15 steps from D-glucosamine derivative 2 in total 16% yield. The analogue exhibits Limulus activity and cytokine-inducing activity similar to the natural lipopolysaccharide and the unlabeled PE analogue oflipidA.

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