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Synthesis and binding affinity at α4β2 and α7 nicotinic acetylcholine receptors of new analogs of epibatidine and epiboxidine containing the 7-azabicyclo[2.2.1]hept-2-ene ring system

✍ Scribed by Clelia Dallanoce; Carlo Matera; Luca Pucci; Cecilia Gotti; Francesco Clementi; Marco De Amici; Carlo De Micheli


Book ID
113496496
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
617 KB
Volume
22
Category
Article
ISSN
0960-894X

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New synthesis of 7-(tert-butoxycarbonyl)
✍ Lawrence E. Brieaddy; Feng Liang; Philip Abraham; Jeffrey R. Lee; F. Ivy Carroll 📂 Article 📅 1998 🏛 Elsevier Science 🌐 French ⚖ 110 KB

A new, high yield, convenient synthesis of 7-(tert-butoxycarbonyl)-7-azabicyclo[2.2.1 ]hept-2erie which involved the addition of tributyltin hydride to 7-(tert-butoxycarbonyl)-2-p-toluenesulfonyl-7azabicyclo[2.2.1]-2-ene followed by elimination of the tributyltin and p-tolylsulfonyl groups using tet