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Synthesis and application of new organometallic compounds of silicon and germanium in chemical radioprotection

✍ Scribed by G. Rima; J. Satgé; R. Dagiral; C. Lion; M. Fatome; V. Roman; J.-D. Laval

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
106 KB
Volume
13
Category
Article
ISSN
0268-2605

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✦ Synopsis

Several organosilicon and organogermanium compounds possessing radioprotective activity have been synthesized. In this paper, we describe the preparation and study of the pharmacological properties of new organometallic compounds such as metallathiazolidines and metalladithioacetals derived from 1-[N-(2-mercaptoethyl)-2-aminoethyl]-2-(1-naphthylmethyl)-2-imidazoline and 1-[N-(2-mercaptopropyl)-2-aminoethyl]-2-(1-naphthylmethyl)-2-imidazoline.

We have noted a decrease in the toxicity and a rather important increase in the radioprotective activity of these new organometallic derivatives in comparison with the starting organic compounds.

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The electron impact and chemical ionisation mass spectra of a number of organometallic derivatives of silicon, germanium, tin and lead, incorporating inter alia 2-bis(trimethylsilyl)methylpyridyl or cyclopentadienyl ligands have been recorded. Representative spectra are presented and illustrate the