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Synthesis and Application of N-Hydroxylamine Derivatives as Potential Replacements for HOBt

✍ Scribed by Ayman El-Faham; Fernando Albericio

Book ID
102177040
Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
115 KB
Volume
2009
Category
Article
ISSN
1434-193X

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✦ Synopsis

Abstract

Several heterocycles containing N‐hydroxylamine were prepared and tested as coupling additives to replace the use of N‐hydroxybenzotriazole (HOBt) derivatives. On the basis of our results on coupling yield and racemization‐suppressing properties, we propose N‐hydroxyindolin‐2‐one and 6‐chloro‐N‐hydroxy‐2‐phenylbenzimidazole as suitable substitutes for HOBt.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)

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