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Synthesis and antiviral screening of some novel pyridazine and triazolopyridazine nucleosides

✍ Scribed by Aymn E. Rashad; Ahmed H. Shamroukh; Mohamed A. Ali; Faiza M. Abdel-Motti

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
242 KB
Volume
18
Category
Article
ISSN
1042-7163

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✦ Synopsis

Abstract

Some novel cyclic and acyclic pyridazine and triazolopyridazine nucleoside derivatives were prepared. Some of the prepared products were selected and tested for antiviral activity against herpes simplex virus type‐1 (HSV‐1) and hepatitis‐A virus (HAV, MBB‐cell culture adapted strain). Plaque reduction infectivity assay was used to determine virus count reduction as a result of treatment with test compounds. Compound 15 showed the highest effect on the HAV than the other tested compounds. Β© 2007 Wiley Periodicals, Inc. Heteroatom Chem 18:274–282, 2007; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20296

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