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Synthesis and Antiviral Activity of the α-Analogues of 1,5-Anhydrohexitol Nucleosides (1,5-Anhydro-2,3-dideoxy- d -ribohexitol Nucleosides)

✍ Scribed by Hossain, Nafizal; Rozenski, Jef; De Clercq, Erik; Herdewijn, Piet


Book ID
127362386
Publisher
American Chemical Society
Year
1997
Tongue
English
Weight
168 KB
Volume
62
Category
Article
ISSN
0022-3263

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Synthesis and antiviral activity of 2-de
✍ María-Jesús Pérez-Pérez; Erik De Clercq; Piet Herdewijn 📂 Article 📅 1996 🏛 Elsevier Science 🌐 English ⚖ 210 KB

Nucleoside analogues containing a 2-deoxy-l,5-anhydro-D-mannitol and a pyrimidine base moiety were synthesized starting from D-glucose via a nucleophilie opening of an epoxide with the heterocyelic base and an inversion of configuration at the 3'-position. Study of the conformation of these molecule