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Synthesis and antiviral activity of 3-substituted derivatives of 3,9-dihydro-9-oxo-5H-imidazo[1,2-a]purines, tricyclic analogs of acyclovir and ganciclovir

✍ Scribed by Boryski, Jerzy; Golankiewicz, Bozenna; De Clercq, Erik


Book ID
120240962
Publisher
American Chemical Society
Year
1991
Tongue
English
Weight
555 KB
Volume
34
Category
Article
ISSN
0022-2623

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## Abstract A series of eleven 2‐ and 6‐substituted (__R,S__)‐9‐(2,3‐dihydro‐1,4‐benzoxathiin‐3‐ylmethyl)‐9__H__‐purine derivatives was obtained by applying a standard Mitsunobu protocol that led to a six‐membered ring contraction from (__R,S__)‐3,4‐dihydro‐2__H__‐1,5‐benzoxathiepin‐3‐ol via an epi