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Synthesis and antitumour activity of sulfoalkyl derivatives of curdlan and lichenan

✍ Scribed by Sabine Demleitner; Josef Kraus; Gerhard Franz

Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
366 KB
Volume
226
Category
Article
ISSN
0008-6215

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✦ Synopsis

2-Sulfoethyl, 3-sulfopropyl, and 4-sulfobutyl derivatives of the (1----3)-beta-D-glucan curdlan and the (1----3/1----4)-beta-D-glucan lichenan have been synthesised. The substituents are located mainly at positions 6. The curdlan derivatives strongly inhibited the growth of the Sarcoma 180 tumour, whereas the lichenan derivatives were inactive, indicating that a (1----3)-linked beta-D-glucan backbone is essential for activity.

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