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Synthesis and antitumor activity of spin labeled derivatives of podophyllotoxin

โœ Scribed by Xuan Tian; Yan-gwang Wang; Ming-gui Yang; Yao-zu Chen


Book ID
117174837
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
393 KB
Volume
60
Category
Article
ISSN
0024-3205

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Synthesis and antitumor activity of podo
โœ Kiyoshi Tomioka; Yoshihiro Kubota; Kenji Koga ๐Ÿ“‚ Article ๐Ÿ“… 1989 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 157 KB

## Podophyllotoxin aza-analogue 7 (3 RI =H, Rz=Me, H) was designed and synthesized by a highly stereoselective condensation reaction of a cyclic urethane 5 with 3,4,5-trimethoxybenzaldehyde 6 and was found to show a promising in vitro and in vivo antitumor activity. Podophyllotoxin