Synthesis and antitumor activity of novel pyrazolylenaminone and bis(pyrazolyl)ketones via hydrazonoyl halides

✍ Scribed by Ahmad S. Shawali; Sherif M. Sherif; Mahmoud M. El-Merzabani; Manal A. A. Darwish

• Publisher: Journal of Heterocyclic Chemistry
• Year: 2009
• Tongue: English
• Weight: 103 KB
• Volume: 46
• Category: Article
• ISSN: 0022-152X
• DOI: 10.1002/jhet.113

✦ Synopsis

Abstract

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3‐Acetyl‐4‐benzoyl‐1,5‐diphenylpyrazole reacts with DMF‐DMA to give the novel enaminone 2. The reaction of the latter with various hydrazonoyl halides afforded regioselectively the respective substituted (3‐pyrazolyl)(4‐pyrazolyl)ketones 4 in good over all yield. The preliminary screening for the antitumor activity of the synthesized compounds 2 and 4a, 4b, 4c, 4d, 4e, 4f, 4g against human breast cancer cell line (MCF‐7) revealed that both compounds 2 and 4b have high‐antitumor activity. SAR is discussed. J. Heterocyclic Chem., 46, 548 (2009).