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Synthesis and Antitumor Activity of New Glycosides of Epipodophyllotoxin, Analogues of Etoposide, and NK 611

✍ Scribed by Daley, Laurent; Guminski, Yves; Demerseman, Pierre; Kruczynski, Anna; Etiévant, Chantal; Imbert, Thierry; Hill, Bridget T.; Monneret, Claude

Book ID: 121194211
Publisher: American Chemical Society
Year: 1998
Tongue: English
Weight: 272 KB
Volume: 41
Category: Article
ISSN: 0022-2623
DOI: 10.1021/jm9800752

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## Abstract 8,8‐Dimethyl‐5,6,7,8‐tetrahydrophenanthrene‐3,4‐dione (3) and 8,8‐dimethyl‐2‐(l‐hydroxy ethyl)‐5,6,7,8‐tetrahydrophenanthrene‐3,4‐dione (4), two analogues of the antitumor active tanshinone, were synthesized from anisole. The synthesized compounds 3 and 4 were shown to be highly active