Synthesis and antitumor activity of 7-ethyl-9-alkyl derivatives of camptothecin
โ Scribed by Heyong Gao; Xiongwen Zhang; Yi Chen; Hongwu Shen; Jing Sun; Min Huang; Jian Ding; Chuan Li; Wei Lu
- Book ID
- 108073596
- Publisher
- Elsevier Science
- Year
- 2005
- Tongue
- English
- Weight
- 118 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0960-894X
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Novel water-soluble camptothecin analogues with excellent antitumor activity have been designed and synthesized by total synthesis. The analogues were evaluated for cytotoxic activity against five tumor cell lines. The most potent analogue 6e exhibited significant antitumor activity at wider range o
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