Synthesis and antitumor activity of (2R,3R)-2,3-dihydroxy- and -2,3-dialkoxy-1,4-diaminobutane platinum(II) complexes
โ Scribed by Dae-Kee Kim; Jongsik Gam; Yong-Baik Cho; Hun-Taek Kim; Key H. Kim
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 306 KB
- Volume
- 6
- Category
- Article
- ISSN
- 0960-894X
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
2R,3R)-Dihydroxy-tetrahydronaphthalene, prepared via an efficient chemoenzymatic procedure from naphthalene, has been successfully tested, as a chiral auxiliary in diastereoselective conjugate additions of lithium dialkylcuprates to 0t,13-unsaturated esters and in stereoselective alkylations of 13-k
Nine new water-soluble platinum(I1) complexes were synthesized and characterized. Racemic ( f )-2-benzyl-1,2diaminobutane or the corresponding enantiomers (+)-2-benzyl-1,2-diaminobutane and (-)-2-benzyl-l,Zdiaminobutane were used as nitrogen chelate ligands. The chloride leaving groups of the result