Synthesis and antitumor activity of 10-propargyl-10-deazaaminopterin
โ Scribed by DeGraw, Joseph I.; Colwell, William T.; Piper, James R.; Sirotnak, Francis M.
- Book ID
- 121306322
- Publisher
- American Chemical Society
- Year
- 1993
- Tongue
- English
- Weight
- 409 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0022-2623
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
vevsi ty o f South A1 abama Mobile, AL 36688 SUMARY 10-Deazaaminopterin (1) and 10-Ethyl-10-deazaaminopterin ( 2 ) labeled uniformly w i t h 14C a t the glutamate moiety were prepared by the following procedure. Uniformly labeled L-glutamic acid was converted t o i t s dimethyl ester (3). -4-Amino-
The antifolate compounds IOdeazaaminopterin (lOdAM) and IO-ethyl-IOdeazaaminopterin ( IO-EdAM) are therapeutically superior to methotrexate in transplanted murine tumor systems and in human tumor xenografts growing in immunodeficient "nude" mice. The increased therapeutic index of these analogs corr