✦ LIBER ✦

Synthesis and antitumor activities of 2-(substituted)phenyl-1,2,4-triazolo[1,5-a]pyridines

✍ Scribed by Guolin Zhang; Yongzhou Hu

Publisher: Journal of Heterocyclic Chemistry
Year: 2007
Tongue: English
Weight: 232 KB
Volume: 44
Category: Article
ISSN: 0022-152X
DOI: 10.1002/jhet.5570440428

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✦ Synopsis

Abstract

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Twenty‐three 2‐(substituted)phenyl‐1,2,4‐triazolo[1,5‐a]pyridines have been synthesized by cycloadditison reaction between N‐amino methylpyridinium mesitylenesulfonates and substituted benzonitriles under the presence of potassium hydroxide at room temperature. The structures of all products were confirmed by ^1^H NMR, MS and elemental analyses. The antitumor activities of these compounds were evaluated against human ovary cancer cell line (HO‐8910) in vitro by MTT method. The preliminary results showed that compound 1e (IC~50~ 28μM) and compound 1w (IC~50~ 31μM) exhibited stronger antitumor activities than cisplatin (IC~50~ 35μM) in vitro. Hence, 1e and 1w have potential antitumor activities and are worth further investigation.

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