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Synthesis and antiproliferative activity of A-ring aromatised and conduritol-like steroidal compounds

✍ Scribed by Dragana Milić; Tatjana Kop; Zorica Juranić; Miroslav J. Gašić; Bernard Tinant; Gabriella Pocsfalvi; Bogdan A. Šolaja


Book ID
116891854
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
325 KB
Volume
70
Category
Article
ISSN
0039-128X

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Synthesis and antiproliferative activity
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The chemical synthesis of cytidine-5'-alkyl-and cytidine-5'-alkyl(acyl)deoxyglycerophosphonophosphates is reported. The compounds obtained represent a novel class of cytostatically active agents based on phospholipids, which inhibit the growth of various tumor cell lines in vitro. They are phosphono