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Synthesis and Antiproliferative Activity of Substituted Benzopyranoisoindoles: A New Class of Cytotoxic Compounds.

✍ Scribed by Christiana Hadjipavlou; Ioannis K. Kostakis; Nicole Pouli; Panagiotis Marakos; Harris Pratsinis; Dimitris Kletsas


Publisher
John Wiley and Sons
Year
2006
Weight
29 KB
Volume
37
Category
Article
ISSN
0931-7597

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## Abstract A series of __N__‐substituted pyrazole derivatives have been synthesized and tested for their anticancer effect on the HL‐60 leukaemia cell line. Four were active both in cell‐growth inhibition and in inducing apoptosis. The inhibition of cell growth mainly reflects a compound‐induced r