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Synthesis and antiplatelet activity of some 1,8-naphthyridine derivatives

✍ Scribed by PL Ferrarini; C Mori; M Miceli; F Franconi

Publisher
Elsevier Science
Year
1994
Tongue
French
Weight
556 KB
Volume
29
Category
Article
ISSN
0223-5234

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Unusual nitration of substituted 7-amino
Unusual nitration of substituted 7-amino-1,8-naphthyridine in the synthesis of compounds with antiplatelet activity
✍ Pier Luigi Ferrarini; Claudio Mori; Muwaffag Badawneh; Clementina Manera; Adrian πŸ“‚ Article πŸ“… 1997 πŸ› Journal of Heterocyclic Chemistry 🌐 English βš– 546 KB

## Abstract Several 1,8‐naphthyridine derivatives have been diazotizated to obtain the corresponding hydroxy derivatives or mixture of hydroxy and hydroxy nitro derivatives. The respective amounts of hydroxy and hydroxy nitro derivatives depends on the nature of the substituents, on their position

ChemInform Abstract: Unusual Nitration o
ChemInform Abstract: Unusual Nitration of Substituted 7-Amino-1,8-naphthyridine in the Synthesis of Compounds with Antiplatelet Activity.
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Unusual Nitration of Substituted 7-Amino-1,8-naphthyridine in the Synthesis of Compounds with Antiplatelet Activity. -If higher amounts than 0.2-0.25 equivalents of NaNO 2 are used for the title reaction decreased yields of the nitro compounds are observed. Mechanistical aspects are also discussed