Synthesis and Antioxidant Activity of 2-Thioxo-1,2,3,4-Tetrahydropyrimidine-5-Carbamides
✍ Scribed by O. V. Kushnir; O. N. Voloshchuk; R. I. Eften’eva; M. M. Marchenko; M. V. Vovk
- Book ID
- 125985812
- Publisher
- Springer
- Year
- 2014
- Tongue
- English
- Weight
- 101 KB
- Volume
- 48
- Category
- Article
- ISSN
- 0091-150X
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Single-crystal X-ray study T = 292 K Mean '(C±C) = 0.002 A Ê R factor = 0.030 wR factor = 0.095 Data-to-parameter ratio = 14.9 For details of how these key indicators were automatically derived from the article, see http://journals.iucr.org/e.
A series of 3-(4,6-disubtituted-2-thioxo-1,2,3,4-tetrahydropyrimidin-5-yl) propanoic acid derivatives has been synthesized by condensation of thiourea, 5-(4-subtituted phenyl)-5-oxopentanoic acid and substituted aldehyde. The synthesized compounds were screened for their anti-inflammatory activity u
In the crystal structure of the title compound, C 16 H 17 N 5 O 2 S, molecules are linked by two N-HÁ Á ÁS hydrogen bonds, with N-S distances of 3.3469 (13) and 3.3703 (13) A ˚and N-H Á Á ÁS angles of 158 and 162 .