✦ LIBER ✦

Synthesis and antineoplastic evaluation of N-enamine derivatives of 1,4-bis[(2-aminoethyl)amino]-9,10-anthracenedione

✍ Scribed by B Stefanska; S Martelli; J Paradziej-Lukowicz; E Borowski

Publisher: Elsevier Science
Year: 1991
Tongue: French
Weight: 399 KB
Volume: 26
Category: Article
ISSN: 0223-5234
DOI: 10.1016/0223-5234(91)90008-b

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Induction of alloreactive immunosuppress

Induction of alloreactive immunosuppression by 1,4-bis [(2-aminoethyl)amino]-5,8-dihydroxy-9,10-anthracenedione dihydrochloride (CL 232,468)

✍ Bosco Shang Wang; Araceli L. Lumanglas; Veronica M. Ruszala-Mallon; Roslyn E. Wa 📂 Article 📅 1984 🏛 Elsevier Science 🌐 English ⚖ 564 KB

Target cell specificity of immunosuppres

Target cell specificity of immunosuppression in murine lymphocytes exposed to 1,4-bis[(2-aminoethyl)amino]-5,8-dihydroxy-9,10-anthracenedione dihydrochloride (AEAD)

✍ Robert V. House; Jack H. Dean 📂 Article 📅 1989 🏛 Elsevier Science 🌐 English ⚖ 726 KB

Structure-activity relationship study of

Structure-activity relationship study of anthraquinones: 1, 4-dihydroxy-5, 8-bis[[2-(2-hydroxyethoxy)ethyl]amino]-9, 10-anthracenedione, an analog of an established antineoplastic agent

✍ Robert K. Y. Zee-Cheng; C. C. Cheng 📂 Article 📅 1982 🏛 John Wiley and Sons 🌐 English ⚖ 188 KB

An oxygen analog of the antineoplastic anthraquinone, 1,4-dihydroxy-5,8-bis[ [2-(2-hydroxyethyl)amino]ethyl)amino -9,lO -anthracenedione, was synthesized. This compound, 1,4-dihydroxy-5,8bis[ [2-(2-hydroxyethoxy)ethyI]amino] -9,10-anthracenedione, was found to be inactive against P-388 lymphocytic l

Pharmacological disposition of 1,4-dihyd

Pharmacological disposition of 1,4-dihydroxy-5-8-bis[[2[(2-hydroxyethal)amino] ethyl]amino]-9,10-anthracenedione dihydrochloride in the dog

✍ Katherine Lu; Niramol Savaraj; Ti Li Loo 📂 Article 📅 1984 🏛 Springer 🌐 English ⚖ 328 KB

D HA Q, a new antitumor agent, has been selected for clinical trial on the basis of its activity against a number of transplantable rodent tumors. In anticipation of the clinical trial of this agent, the pharmacology of DHAQ was studied in beagles by high-pressure liquid chromatographic and radioche

Synthesis of 1-amino- and 1-hydroxy-9,10

Synthesis of 1-amino- and 1-hydroxy-9,10-anthraquinone derivatives based on reaction sequences between 2-acetyl-1,4-naphthoquinone and enamines

✍ Kazuhiro Kobayashi; Masaharu Uchida; Shinya Watanabe; Atsushi Takanohashi; Miyuk 📂 Article 📅 2000 🏛 Elsevier Science 🌐 French ⚖ 141 KB

2-Acetyl-1,4-naphthoquinone was treated with pyrrolidine (or morpholine) enamines, derived from cyclic and acyclic ketones, in DMF at room temperature for 24-72 h to afford 3,4-disubstituted 1-pyrrolidino(or morpholino)-9,10-anthraquinones. On the other hand, when the treatment of 2-acetyl-1,4-napht

Synthesis of Potentially Antineoplastic

Synthesis of Potentially Antineoplastic Derivatives of N-[N-(2-Chloroethyl)-N-nitrosocarbamoyl]amino Acids

✍ Wei-Ci Tang; Gerhard Eisenbrand 📂 Article 📅 1981 🏛 John Wiley and Sons 🌐 English ⚖ 351 KB 👁 2 views

## Abstract The synthesis of __N__‐[__N__‐(2‐chloroethyl)‐__N__‐nitrosocarbamoyl]amino acids and their anilides, congeners of __N__‐(2‐chloroethyl)‐__N__‐nitrosoureas, as potential antineoplastic substances is reported. __N__‐[__N__‐(2‐chloroethyl)‐__N__‐nitrosocarbamoyl]amino acids are prepared by