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Synthesis and antimycobacterial properties of N-substituted 6-amino-5-cyanopyrazine-2-carboxamides

✍ Scribed by Jan Zitko; Martin Dolezal; Michaela Svobodova; Marcela Vejsova; Jiri Kunes; Radim Kucera; Petr Jilek

Book ID: 108072983
Publisher: Elsevier Science
Year: 2011
Tongue: English
Weight: 211 KB
Volume: 19
Category: Article
ISSN: 0968-0896
DOI: 10.1016/j.bmc.2010.12.054

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## Abstract The preparation of several novel 3,5‐substituted‐indole‐2‐carboxamides is described. A 5‐nitro‐indole‐2‐carboxylate was elaborated to the 3‐benzhydryl ester, __N__‐substituted ester, and carboxylic acid intermedi ates, followed by conversion to the amide and then reduction of the 5‐nitr