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Synthesis and antimycobacterial evaluation of N-substituted 5-chloropyrazine-2-carboxamides

✍ Scribed by Servusová, Barbora; Vobicková, Jana; Paterová, Pavla; Kubíček, Vladimír; Kuneš, Jiří; Doležal, Martin; Zitko, Jan


Book ID
125429794
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
350 KB
Volume
23
Category
Article
ISSN
0960-894X

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✍ Larry D. Bratton; Bruce D. Roth; Bharat K. Trivedi; Paul C. Unangst 📂 Article 📅 2000 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 434 KB

## Abstract The preparation of several novel 3,5‐substituted‐indole‐2‐carboxamides is described. A 5‐nitro‐indole‐2‐carboxylate was elaborated to the 3‐benzhydryl ester, __N__‐substituted ester, and carboxylic acid intermedi ates, followed by conversion to the amide and then reduction of the 5‐nitr