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Synthesis and antimycobacterial activity of 1,2,4-triazole 3-benzylsulfanyl derivatives

✍ Scribed by Věra Klimešová; Lenka Zahajská; Karel Waisser; Jarmila Kaustová; Ute Möllmann


Book ID
113619687
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
215 KB
Volume
59
Category
Article
ISSN
0014-827X

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Synthesis and antimycobacterial activity
✍ Boštjan Japelj; Simon Rečnik; Petra Čebašek; Branko Stanovnik; Jurij Svete 📂 Article 📅 2005 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 132 KB

A series of alkyl 1-heteroaryl-1H-1,2,3-triazole-4-carboxylates 6a-u were synthesised in four steps from methyl (Z)-2-benzyloxycarbonylamino-3-(dimethylamino)prop-2-enoate (1) and heterocyclic amines 2a-s. Triazoles 6a-o were tested against antimycobacterial activity. For the most active compound, n