The total synthesis of (-)-hemiasterlin (2), a structurally novel, naturally occurring tripeptide that exhibits potent cytotoxic and antimitotic activity against human breast cancer MCF7 cells, is described.
β¦ LIBER β¦
Synthesis and Antimitotic/Cytotoxic Activity of Hemiasterlin Analogues
β Scribed by Nieman, James A.; Coleman, John E.; Wallace, Debra J.; Piers, Edward; Lim, Lynette Y.; Roberge, Michel; Andersen, Raymond J.
- Book ID
- 118273901
- Publisher
- American Chemical Society
- Year
- 2003
- Tongue
- English
- Weight
- 340 KB
- Volume
- 66
- Category
- Article
- ISSN
- 0163-3864
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