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Total synthesis of (−)-hemiasterlin, a structurally novel tripeptide that exhibits potent cytotoxic activity

✍ Scribed by Raymond J Andersen; John E Coleman; Edward Piers; Debra J Wallace

Book ID
104256083
Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
208 KB
Volume
38
Category
Article
ISSN
0040-4039

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✦ Synopsis

The total synthesis of (-)-hemiasterlin (2), a structurally novel, naturally occurring tripeptide that exhibits potent cytotoxic and antimitotic activity against human breast cancer MCF7 cells, is described.

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