Synthesis and antimicrobial evaluation of novel polyheterocyclic ring systems derived from 2-oxo-2H-pyrimido[2,1-b]benzothiazole-3-carbonitrile
✍ Scribed by Bondock, Samir
- Book ID
- 121857663
- Publisher
- Springer Netherlands
- Year
- 2014
- Tongue
- English
- Weight
- 378 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0922-6168
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📜 SIMILAR VOLUMES
## Abstract Reaction of 4__H__‐pyrimido[2,1‐__b__]benzothiazole‐2‐thiomethyl‐3‐cyano‐4‐one **(1)** with hydrazine hydrate/aryl hydrazine/heteryl hydrazine in the presence of anhydrous potassium carbonate and dimethyl formamide afforded 3‐amino‐4‐oxo‐(2__H__)/aryl/heteryl pyrazolo[3′,4′:4,5]pyrimido
## Abstract 2‐Amino‐6‐methoxybenzothiazole **1** on reaction with bis(methylthio)methylene malononitrile **2** in the presence of dimethyl formamide and catalytic amount of anhydrous potassium carbonate afforded 3‐cyano‐4‐imino‐8‐methoxy‐4__H__‐pyrimido[2,1‐__b__][1,3]benzothiazole **3**. Under sim
The 2-(1,2-dihydro-3-oxo-3H-pyrazol-2-yl)benzothiazole scaffold was selected as a central core structure for the discovery of novel antibacterial compounds. A systematic variation of the substituents on the oxo-pyrazole moiety, as well as on the benzo moiety, led to the creation of a small and focus