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Synthesis and antimicrobial activity of novel 3 substituted 1,5-dihydro-2,4,3-benzodioxaphosphepine 3-oxides

✍ Scribed by P. Haranath; M. F. Stephen Babu; U. Anasuyamma; C. Naga Raju; C. Suresh Reddy

Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
73 KB
Volume
16
Category
Article
ISSN
1042-7163

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✦ Synopsis

Abstract

Novel 3 substituted 1,5‐dihydro‐2,4,3‐benzodioxaphosphepine 3‐oxides (5a–h) were synthesized by reacting 1,2‐benzenedimethanol (1) with phosphorus tribromide in the presence of triethylamine at 0–30°C and subsequent reaction of the monobromide (2) with different Grignard reagents (3) at room temperature. The products (4) were converted to corresponding oxides 5a–i by oxidation with H~2~O~2~ at room temperature. The chemical structures of all the products were confirmed by analytical, IR and NMR (^1^H, ^13^C, and ^31^P) spectral data. Their antifungal and antibacterial activity is also evaluated. Most of these compounds exhibited moderate antimicrobial activity in the assay. © 2005 Wiley Periodicals, Inc. Heteroatom Chem 16:572–575, 2005; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20154

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