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Synthesis and antimicrobial activity of novel 1,3,4-oxadiazolyl-quinazolin-4(3H)ones

✍ Scribed by Navin B. Patel; Jaymin C. Patel

Publisher
Journal of Heterocyclic Chemistry
Year
2010
Tongue
English
Weight
135 KB
Volume
47
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

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A series of 1,3,4‐oxadiazolyl‐quinazolin‐4(3__H__)ones have been synthesized using known methods. All the compounds have been established on basis of elemental analysis, IR and NMR spectral data. The in vitro antimicrobial screening of the synthesized compounds were carried out against two gram‐positive bacteria (S. aureus, S. pyogenes), two gram‐negative bacteria (E. coli, P. aeruginosa), and three fungal species (C. albicans, A. niger, A. clavatus) using the broth microdilution method. The compounds 7d, 7g, 7l, 7o, 7p, and 7r possessed pronounced antibacterial activity whereas compound 7p exhibited promising antifungal activity. J. Heterocyclic Chem., (2010).

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