Synthesis and antimicrobial activity of geminal bis-hydroperoxides
✍ Scribed by V. I. Tropina; O. V. Krivykh; N. P. Sadchikova; A. O. Terent’ev; I. B. Krylov
- Publisher
- Springer
- Year
- 2010
- Tongue
- English
- Weight
- 70 KB
- Volume
- 44
- Category
- Article
- ISSN
- 0091-150X
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A new class of methyleneamine-linked bis-heterocycles that exhibit antimicrobial activity was synthesized. Bromination of 1 followed by condensation with thiourea gave 3. The reaction of 3 with propargyl bromide in dry toluene under inert atmosphere led to the formation of 4. Its subsequent reaction
## Abstract Syntheses of novel [{(3‐dialkoxy‐phosphoryl)‐(substituted‐phenyl‐methyl)‐2‐oxo‐2‐phenyl‐2,3‐dihydro‐2λ^5^–benzo [1,3,2] diazaphosphol‐1‐yl}‐(substituted‐phenyl)‐methyl]‐phosphonic acid diethyl/dimethyl esters (**3a**, **3b**, **3c**, **3d**, **3e**, **3f**, **3g**, **3h**, **3i**, **3j*