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Synthesis and Antimicrobial Activities of Oximes Derived from O-Benzylhydroxylamine as FabH Inhibitors

✍ Scribed by Dr. Yin Luo; Dr. Li-Rong Zhang; Dr. Yang Hu; Dr. Shuai Zhang; Dr. Jie Fu; Prof. Xiao-Ming Wang; Prof. Hai-Liang Zhu


Book ID
112066729
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
641 KB
Volume
7
Category
Article
ISSN
1860-7179

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Fatty acid biosynthesis is essential for bacterial survival. FabH, b-ketoacyl-acyl carrier protein (ACP) synthase III, is a particularly attractive target, since it is central to the initiation of fatty acid biosynthesis and is highly conserved among Gram-positive and -negative bacteria. Fifty-six 1