Design, synthesis and antimicrobial activities evaluation of Schiff base derived from secnidazole derivatives as potential FabH inhibitors
β Scribed by Li, Yao; Zhao, Chang-Po; Ma, Hua-Ping; Zhao, Meng-Yue; Xue, Ya-Rong; Wang, Xiao-Ming; Zhu, Hai-Liang
- Book ID
- 120083590
- Publisher
- Elsevier Science
- Year
- 2013
- Tongue
- English
- Weight
- 460 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0968-0896
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Fatty acid biosynthesis is essential for bacterial survival. FabH, b-ketoacyl-acyl carrier protein (ACP) synthase III, is a particularly attractive target, since it is central to the initiation of fatty acid biosynthesis and is highly conserved among Gram-positive and -negative bacteria. Fifty-six 1
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A novel series of thiazolyl Schiff bases have been designed and synthesized. These new compounds were obtained by the reactions of 4-phenyl-5-(1H-1,2,4-triazol-1-yl) thiazol-2-amine and substituted aromatic aldehydes and were characterized on the basis of 1 H NMR and elemental analysis. The newly sy