Synthesis and antimalarial effects of 5,6-dichloro-2-[(4-||4-(diethylamino)-i-methylbutyl] amino||-6-methyl-2-pyrirnidinyl)amino] benzimidazole and related benzimidazoles and lH-imidazo[4,5-b] pyridines
✍ Scribed by Leslie M. Werbel; Ann Curry; Edward F. Elslager; Carolyn Hess
- Book ID
- 112122947
- Publisher
- Journal of Heterocyclic Chemistry
- Year
- 1973
- Tongue
- English
- Weight
- 980 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0022-152X
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## Abstract The syntheses of the deuterium‐labeled food mutagen 2‐amino‐1‐methyl‐6‐phenyl‐1H‐imidazo[4,5‐b]pyridine (PhIP) and its __N__‐hydroxy metabolite are described. Unlabeled PhIP is deuterated using a boron trifluoride phosphoric acid complex in one step. Labeled PhIP–^2^H~5~ is nitrosated t
## Abstract magnified image Synthesis of 2‐amino‐1‐methyl‐6‐phenylimidazo[4,5‐__b__]pyridine (PhIP), three structural isomers, and two desphenyl PhIP congeners has been carried out. Mutagenic potency was evaluated using __S. typhimurium__ strain TA98 in the Ames test. Mutagenic potency increased i