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Synthesis and antimalarial activity of new 1,2,4,5-tetroxanes and novel alkoxy-substituted 1,2,4,5-tetroxanes derived from primary gem-dihydroperoxides

✍ Scribed by Hans-Jürgen Hamann; Mandy Hecht; Alexander Bunge; Malgorzata Gogol; Jürgen Liebscher

Publisher
Elsevier Science
Year
2011
Tongue
French
Weight
521 KB
Volume
52
Category
Article
ISSN
0040-4039

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✦ Synopsis

a b s t r a c t

A convenient synthesis of new unsymmetrically substituted 1,2,4,5-tetroxanes and novel unsymmetrical alkoxy-substituted 1,2,4,5-tetroxanes starting from primary dihydroperoxides was developed. The structure of some tetroxanes was unambiguously assigned by X-ray crystal analysis giving interesting insights in the configuration and conformation of disubstituted 1,2,4,5-tetroxanes. Some of these tetroxanes showed notable antimalarial activity in vitro.

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