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Synthesis and Antileishmanial Activities of Novel 3-Substituted Quinolines

✍ Scribed by Tempone, A. G.; Pompeu da Silva, A. C. M.; Brandt, C. A.; Martinez, F. S.; Treiger Borborema, S. E.; Barata da Silveira, M. A.; de Andrade, H. F.

Book ID: 121866464
Publisher: American Society for Microbiology
Year: 2005
Tongue: English
Weight: 294 KB
Volume: 49
Category: Article
ISSN: 0066-4804
DOI: 10.1128/AAC.49.3.1076-1080.2005

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## Abstract A synthesis of quinoline derivatives is described __via__ reaction between ethyl bromopyruvate (=ethyl 3‐bromo‐2‐oxopropanoate), acetylenedicarboxylate, and isatin (=1__H__‐indole‐2,3‐dione) in the presence of NaH as a base. Also, these reactions were performed without ethyl bromopyruva