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Synthesis and antihypertensive activity of 4'-substituted spiro[4H-3,1-benzoxazine-4,4'-piperidin]-2(1H)-ones

โœ Scribed by Clark, Robin D.; Caroon, Joan M.; Kluge, Arthur F.; Repke, David B.; Roszkowski, Adolph P.; Strosberg, Arthur M.; Baker, Stephen; Bitter, Susan M.; Okada, Marlys D.


Book ID
120060040
Publisher
American Chemical Society
Year
1983
Tongue
English
Weight
706 KB
Volume
26
Category
Article
ISSN
0022-2623

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Synthesis of 3-substituted-4H-1,4-benzox
โœ L. Chacun-Lefevre; C. Buon; P. Bouyssou; G. Coudert ๐Ÿ“‚ Article ๐Ÿ“… 1998 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 98 KB

Various 3-substituted-4H-1,4-benzoxazines were prepared in good yields by lithiation-electrophilic substitution of the 4-Boc-4H-l,4-benzoxazine. The synthesis of this carbamic derivative, in four steps from 2aminophenol, was described.