Synthesis and Antifungal Studies on New Organic Sulfur Compounds * *College of Pharmacy, State University of Iowa, Iowa City

✍ Scribed by Shah, Amrutlal M. ;Jones, James W.

• Publisher: Elsevier
• Year: 1958
• Weight: 270 KB
• Volume: 47
• Category: Article
• ISSN: 0095-9553
• DOI: 10.1002/jps.3030470605

✦ Synopsis

Six derivatives of o-phenylenediamine-bis-dithiocarbamic acid and six derivatives of 4-chloro-o-phenylenediamine-bis-dithiocarbamic acid were prepared. Twelve new compounds, undecylenic acid and ethanol were screened for antimycotic activity against M. Gypseum, M . a n i s , T. Rubrum, and T. Mentagropbyte by agar plate, paper-disk technique. All the compounds were more effective than undecylenic acid against all of the organisms with exception of the sodium salts of o-phenylenediamine-bis-dithiocarbamic acid which was more effective only against M . Canis and T. Rubrum.

ITAL STATISTICS reveals t h a t fungal diseases vof men are growing health problems (1).