Synthesis and antifungal evaluation of novel dicyanoderivatives of rhodanine

✍ Scribed by Braulio Insuasty; Alberto Insuasty; Alexis Tigreros; Jairo Quiroga; Rodrigo Abonia; Manuel Nogueras; Justo Cobo; Marcos Derita; Susana Zacchino

• Book ID: 102343191
• Publisher: Journal of Heterocyclic Chemistry
• Year: 2010
• Tongue: English
• Weight: 122 KB
• Volume: 48
• Category: Article
• ISSN: 0022-152X
• DOI: 10.1002/jhet.565

✦ Synopsis

Abstract

This work describes the synthesis and antifungal evaluation of 5‐arylidene‐(Z)‐2‐(1,1‐dicyanomethylene)‐1,3‐thiazol‐4‐ones 5 obtained from the reaction of 2‐(1,1‐dicyanomethylene)‐1,3‐thiazol‐4‐one 3 and benzaldehydes 4. The starting material 3 was synthesized by a condensation reaction of rhodanine 1 and malononitrile 2. The structures of the obtained products were established by IR, NMR, mass spectrometry, and elemental analysis. J. Heterocyclic Chem., (2011).