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Synthesis and antifertility activity of ω-chain phenyl- and 16-phenoxy-analogues of (±)-11-deoxyprostaglandin F1α

✍ Scribed by B.J. Broughton; M.P.L. Caton; E.C.J. Coffee; D.J. Hambling; M.N. Palfreyman; M.T. Withnall; K.R.H. Wooldridge

Book ID
119488580
Publisher
Elsevier Science
Year
1980
Tongue
English
Weight
695 KB
Volume
19
Category
Article
ISSN
0090-6980

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✍ Francisco S. Alvarez; Douglas Wren 📂 Article 📅 1973 🏛 Elsevier Science 🌐 French ⚖ 211 KB

We wish to report an efficient synthesis of 11-deoxy PGElg, 11-deoxy PGFlc, and ll-deoxy PGFl5 and its 158 epimers via the key intermediate 2-(6'-carbomethoxyhexyl)-cyclopenten-1-one-3-carboxaldehyde (6). Michael addition of nitromethane to the ketone 1 7a , catalyzed with tetra-2 methylguanidine ,