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Synthesis and anticonvulsant evaluation of a series of (R)- and (S)-N-Cbz-α-aminoglutarimide and succinimide

✍ Scribed by Minsoo Park; Jaewon Lee; Jongwon Choi


Book ID
103983438
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
285 KB
Volume
6
Category
Article
ISSN
0960-894X

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✍ A. Michael Crider; Thomas M. Kolczynski; David L. Miskell 📂 Article 📅 1981 🏛 John Wiley and Sons 🌐 English ⚖ 449 KB

Several derivatives of' (R,S)-2-amino-N-substituted succinimides were synthesized and evaluated in mice against seizures produced by electroshock and pentylenetetrazol. The most active compound against both electroshock-and pentylenetetrazol-induced seizures was (R,S)-N-benzyl-2-(methanesulfamido)su