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Synthesis and anticonvulsant activity of racemic 2-amino-N-substituted succinimide derivatives

✍ Scribed by A. Michael Crider; Thomas M. Kolczynski; David L. Miskell

Publisher: John Wiley and Sons
Year: 1981
Tongue: English
Weight: 449 KB
Volume: 70
Category: Article
ISSN: 0022-3549
DOI: 10.1002/jps.2600700220

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✦ Synopsis

Several derivatives of' (R,S)-2-amino-N-substituted succinimides were synthesized and evaluated in mice against seizures produced by electroshock and pentylenetetrazol. The most active compound against both electroshock-and pentylenetetrazol-induced seizures was (R,S)-N-benzyl-2-(methanesulfamido)succinimide.

Keyphrases 0 2-Amino-N-substituted succinimide derivatives-synthesis and evaluation for anticonvulsant activity 0 Anticonvulsant activity-2-amino-N-substituted succinimide derivatives, synthesis and evaluation for activity Structure-activity relationships-2-amino-N-substituted succinimide derivatives, synthesis and evaluation for anticonvulsant activity

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