๐”– Bobbio Scriptorium
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Synthesis and Anticonvulsant Evaluation of 5-Vinyl-pyrrolidin-2-ones: A Potential GABA-AT Inhibitor.

โœ Scribed by Tae-Woo Kwon; Pan-Suk Kwon; Suk-Jin Song; Min-Soo Park; Jong-Won Choi


Publisher
John Wiley and Sons
Year
2010
Weight
29 KB
Volume
33
Category
Article
ISSN
0931-7597

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A novel series of dihydrofolate reductase inhibitors was uncovered during an expansion of the SAR of 5,10-dideazatetrahydrofolic acid, and their biological activity was evaluated. These new analogs do not possess an oxygen at the 4 position and contain a monocyclic pyrimidine ring.

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