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Synthesis and anticonvulsant activity of some 2-(N-substituted glycylamino)-4-methyl thiazoles

✍ Scribed by Monique Bachir; Jean-Pierre Riffaud; Jean-Yves Lacolle; Jean Lemoine; Antonio De Almeida; Patrick Houziaux; Bernard Danrée

Publisher
Elsevier Science
Year
1990
Tongue
French
Weight
354 KB
Volume
25
Category
Article
ISSN
0223-5234

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Several derivatives of' (R,S)-2-amino-N-substituted succinimides were synthesized and evaluated in mice against seizures produced by electroshock and pentylenetetrazol. The most active compound against both electroshock-and pentylenetetrazol-induced seizures was (R,S)-N-benzyl-2-(methanesulfamido)su