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Synthesis and anticonvulsant activity of dihydrochlorides of indoline-3′spiro-1-(1,2,3,4-tetrahydro-β-carboline derivatives

✍ Scribed by S. A. Pogosyan; N. P. Grigoryan; R. G. Paronikyan

Publisher: Springer
Year: 2007
Tongue: English
Weight: 80 KB
Volume: 41
Category: Article
ISSN: 0091-150X
DOI: 10.1007/s11094-008-0002-4

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## Abstract Reaction of tryptamine (1) with 2 and 3 gives the enamino ketones 4a and 5, resp., which on treatment with trifluoroacetic acid lead to the 2‐substituted indoles 8 and 9, respectively. Acylation of 4a followed by reaction with trifluoroacetic acid or a Lewis acid affords the 1,2,3,4‐tet