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Synthesis and anticonvulsant activity of bioisosteres of trimethadione, N-derivative-1,2,3-oxathiazolidine-4-one-2,2-dioxides from α-hydroxyamides

✍ Scribed by Pastore, Valentina; Sabatier, Laureano; Enrique, Andrea; Marder, Mariel; Bruno-Blanch, Luis E.


Book ID
118270827
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
401 KB
Volume
21
Category
Article
ISSN
0968-0896

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## Abstract Alkylation of 3‐oxo‐1,2‐thiazetidine 1,1‐dioxide 2 yields the __N__‐alkylated 3‐oxo‐β‐sultams 3a‐i. Solvolysis with NaOH or NH~3~ selectively opens the NS bond forming the sulfonate carboxamides 4 and the sulfonamidocarboxamides 7, respectively. Furthermore, the hitherto unknown compou