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Synthesis and anticholinesterase activity of (−)-physostigmine analogues with modifications at C3aand C5

✍ Scribed by Wang, Hui-jing; Zhang, Dan; Wang, Fu-sheng; Wu, Yi; Song, Hao


Book ID
121618752
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
547 KB
Volume
29
Category
Article
ISSN
1005-9040

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AbstractÐAmong the hapalosin derivatives synthesized, the compounds carrying methyl (5a), methylthioethyl (5d) and phenylmethyl (5e) groups at the C12 position possess only the cis-peptide structure, in contrast to the cases of 5b and 5c. In addition to their conformational stability, the biological