✦ LIBER ✦

Synthesis and antibacterial activity of cephalosporins having C-3 catechol-containing (pyridinium-4′-thio)-methyl groups

✍ Scribed by Koichi Tsuji; Koichi Yasumura; Hiroshi Ishikawa

Publisher: Elsevier Science
Year: 1995
Tongue: English
Weight: 171 KB
Volume: 5
Category: Article
ISSN: 0960-894X
DOI: 10.1016/0960-894x(95)00143-h

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✦ Synopsis

Cephalosporins with catechol-containing (pyridinium-4'-thio)methyl groups at C-3 have been synthesized and examined their antibacterial activity. They were found to have high potency against gram-negative bacteria including Pseudomonas aeruginosa. In particular, compound 9e bearing {I'-[N-(3",4"dihydroxybenzamide)earhamoylmethyl]pyridinium-4'-thio}methyl group at C-3 exhibited excellent antipseudomonal in vivo efficacy.

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